“Case Studies in Modern Drug Discovery and Development”

Using case studies of successful drug discoveries and launches, this book helps master the necessary knowledge of the drug discovery process. It includes pharmacology, drug metabolism, biology, drug development, and clinical studies. The introduction provides an overview of process, principles, and technologies and each chapter contains case studies that focus on one therapeutic target. It also offers stories from patients who have used the drugs covered as a way to illustrate the impact medicinal chemistry has on real life.

Key Topics Covered:

CHAPTER 1 INTRODUCTION: DRUG DISCOVERY IN DIFFICULT TIMES

CHAPTER 2 DISCOVERY AND DEVELOPMENT OF THE DPP-4 INHIBITOR JANUVIA(SITA-GLIPTIN)

CHAPTER 3 OLMESARTAN MEDOXOMIL: AN ANGIOTENSIN II RECEPTOR BLOCKER

CHAPTER 4 DISCOVERY OF HETEROCYCLIC PHOSPHONIC ACIDS AS NOVELAMPMIMICS THAT ARE POTENT AND SELECTIVE FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS AND ELICIT POTENT GLUCOSE-LOWERING EFFECTS IN DIABETIC ANIMALS AND HUMANS

CHAPTER 5 SETTING THE PARADIGM OF TARGETED DRUGS FOR THE TREATMENT OF CANCER: IMATINIB AND NILOTINIB, THERAPIES FOR CHRONIC MYELOGENOUS LEUKEMIA

CHAPTER 6 AMRUBICIN, A COMPLETELY SYNTHETIC 9-AMINOANTHRACYCLINE FOR EXTENSIVE-DISEASE SMALL-CELL LUNG CANCER

CHAPTER 7 THE DISCOVERY OF DUAL IGF-1R AND IR INHIBITOR FQIT FOR THE TREATMENT OF CANCER

CHAPTER 8 DISCOVERY AND DEVELOPMENT OF MONTELUKAST (SINGULAIR&reg)

CHAPTER 9 DISCOVERY AND DEVELOPMENT OF MARAVIROC, A CCR5 ANTAGONIST FOR THE TREATMENT OF HIV INFECTION

CHAPTER 10 DISCOVERY OF ANTIMALARIAL DRUG ARTEMISININ AND BEYOND

CHAPTER 11 DISCOVERY AND PROCESS DEVELOPMENT OF MK-4965, A POTENT NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR

CHAPTER 12 DISCOVERY OF BOCEPREVIR AND NARLAPREVIR: THE FIRST AND SECOND GENERATION OF HCV NS3 PROTEASE INHIBITORS

CHAPTER13 THE DISCOVERYOFSAMSCA (TOLVAPTAN):THEFIRST ORAL NONPEPTIDE VASOPRESSIN RECEPTOR ANTAGONIST

CHAPTER 14 SILODOSIN

CHAPTER 15 RALOXIFENE: A SELECTIVE ESTROGEN RECEPTOR MODULATOR (SERM)

APPENDIX I SMALL MOLECULE DRUG DISCOVERY AND DEVELOPMENT PARADIGM

APPENDIX II GLOSSARY

APPENDIX III ABBREVIATIONS

Author

Xianhai Huang.

Robert G. Aslanian.

For more information visit http://www.researchandmarkets.com/research/tqh6b4/case_studies_in_mo

Source: John Wiley and Sons Ltd