Put the true spirit in your holiday season and come home to Douglasville FUMC for a special Christmas Concert, Sunday December 15, at 5:30PM in the sanctuary at 6167 Prestley Mill Road, Douglasville, GA, 30134.
This annual musical gift to the community will feature both traditional and contemporary holiday favorites, including an amazing piece that will truly drive home the meaning and glory of the Christmas gift. The concert features the Douglasville FUMC Chancel Choir, bells, The Journey Band, children’s choir, members of the Christian Community Orchestra, a magnificent pipe organ, special guest soloists and the ever-popular carol sing! There will truly be something for everyone and every heart will leave lifted.
“We are thrilled to offer this concert as a gift and invite the community to share in this wonderful celebration of the season with us,” said Doug McHenry, Interim Minister of Music, Douglasville FUMC. “This will be an event for all ages that highlights some of most familiar and highest quality music of Christmas. Hearts and voices will be lifted in song. I know that the attendees will leave with the spirit of Christmas alive and well!”
Following the presentation, there will be light refreshments served. There is no charge to attend the concert and all ages are welcome. For more information, please visit Douglasville FUMC online at http://DouglasvilleFUMC.org on Facebook at http://Facebook.com/DouglasvilleFUMC or call the office at 770-942-3146.
Contact
Douglasville First United Methodist Church GA
(770) 942-3146
ST. LOUIS, MO, December 9, 2013 – Scientists at the Donald Danforth Plant Science Center have made several scientific discoveries demonstrating the significant roles Heterotrimeric G proteins play in plant development and yield. Sona Pandey, Ph.D., (http://www.danforthcenter.org/scientists-research/principal-investigators/sona-pandey) principal investigator at the Danforth Plant Science Center and her collaborators have published several papers on their research in recent months.
Pandey and collaborators showed that “G proteins” occur in a wide range of land plants and algae. This discovery was published in the October 2013 issue of Plant Physiology (http://www.plantphysiol.org/content/early/2013/10/31/pp.113.230425.abstract).
“G proteins, alpha, beta and gamma are important because they play critical roles in plants’ development, including fruit and seed size and production, defense against pests and pathogens and response to abiotic stresses such as drought and ozone,” Pandey said. “Understanding their function at the very basic level is an important step in the process of developing products that can be applied to improve crop yield and address environmental issues related to production agriculture.”
Pandey’s research also revealed that when G proteins quantities were elevated in Camelina sativa, the plant produced more seeds, which were also bigger in size. Camelina seeds have very high oil content, leading researchers at the Danforth Center to focus on Camelina to develop biodiesel and other industrial products. Discoveries about the impact of G proteins on seed production and size were published in the September 2013 issue ofPlant Biotechnology (http://www.ncbi.nlm.nih.gov/pubmed/24102738) Journal.
The Pandey lab also showed that G proteins function in soybean roots to affect formation of nitrogen-fixing nodules through a symbiotic relationship with certain beneficial bacteria. These nodules allow soybean to access nitrogen from the atmosphere. The discovery, which could lead to improved crops that require less nitrogen-containing fertilizer, was published in Plant Physiology (http://www.ncbi.nlm.nih.gov/pubmed/23569109) in May, 2013.
Ongoing research in the Pandey lab seeks to understand how G proteins work, and how biochemical reactions involving G proteins evolved in plants. “The research we’ve completed to date is just the tip of the iceburg,” said Pandey. “We believe there is a lot more to learn and then apply to improve agricultural plant productivity.”
About The Donald Danforth Plant Science Center
Founded in 1998, the Donald Danforth Plant Science Center is a not-for-profit research institute with a mission to improve the human condition through plant science. Research aims to feed the hungry and improve human health, preserve and renew the environment and position the St. Louis region as a world center for plant science. The Center’s work is funded through competitive grants and contract revenue from many sources, including the National Institutes of Health, U.S. Department of Energy, National Science Foundation, U.S. Department of Agriculture, U.S. Agency for International Development, the Bill & Melinda Gates and Howard G. Buffett Foundations.
The Danforth Center invites you to visit its website, www.danforthcenter.org, featuring interactive information on the Center scientists, (http://www.danforthcenter.org/scientists-research) recent news (http://www.danforthcenter.org/news-media), the 2012 annual report,and “Roots & Shoots (http://www.danforthcenter.org/news-media/roots-shoots-blog)” blog that help keep visitors up to date with Center’s current operations and areas of research. Follow us on Twitter at @DanforthCenter (http://twitter.com/#!/DanforthCenter).
Kim Lewey, President of National Association of Women Business Owners (NAWBO) Greater Raleigh, announced that they will be holding a 1-hour workshop to cover the basics needed to put together a simple One-Page Business Plan at the January 13, 2014 Greater Raleigh NAWBO meeting featuring Jess McLamb. The workshop will be held at Lafayette Village Executive Suites, 8480 Honeycutt Road, Suite 200 in Raleigh from 6:00pm to 7:00pm. Registration for the workshop is $15 for members, $20 for non-members.
Dedicated to providing the community with opportunities to build business and relationships, the NAWBO January workshop will focus on the methods used to create a simple one-page business plan. Failure to prepare a written business plan is a leading reason 80% of all new businesses in the US fail in the first five years. This 1-hour workshop, with featured speaker Jess McLamb, will educate attendees from the questions to ask to get started to developing sales forecasts and break-even analysis. McLamb will also talk about developing your own financial dashboard to track your key financials.
Jess McLamb, president of Roper Bookkeeping, an accounting company based in Raleigh since 1993, specializes in providing bookkeeping services and QuickBooks consulting to small businesses across the country. McLamb also teaches business workshops through the statewide community college small business centers and SCORE and has trained thousands of entrepreneurs to start and grow their business. Prior to forming Roper Bookkeeping, she was a senior officer in the financial services industry for more than 20 years. She was senior vice president in charge of branch services at First Citizens Bank and vice president of home office services for London Pacific Life & Annuity Co. She is a member of the Greater Raleigh Chamber of Commerce, the Wake County Women Business Owners Network (WBON), and the Greater Raleigh NAWBO.
“Business plans are inherently strategic,” said Lewey. “Many of the techniques described and taught by Jess McLamb are cutting-edge that will increase the understanding and knowledge of the quality and viability of your business’s future.”
Founded in 1978, Greater Raleigh NAWBO propels women entrepreneurs into economic, social and political spheres of power worldwide. Thirty-five years later, NAWBO is still the only organization dedicated solely to representing the interest of women entrepreneurs in all industries. The organization’s mission is to strengthen the wealth-creating capacity of its members and promote economic development; to create innovative and effective change in the business culture; to build strategic alliances, coalitions and affiliations; and to transform public policy and influence decision makers. To learn more about the Greater Raleigh chapter of NAWBO, visit their website at http://www.nawbo-raleigh.org.
MooreCo Inc. is pleased to announce that the Sharewall Full Wall Magnetic Whiteboard has been awarded both the 2013 IIDA Innovation Award for Wall Surfaces and the 2013 Interiors and Sources Magazine Readers' Choice Award for Best Conference Element.
"We are very pleased that Sharewall has been so well received by the architects and designers. It's great to see the A & D community gain confidence that our full wall solution lives up to its reputation," remarked Greg Moore, CEO, "we have especially enjoyed seeing all of the innovative projects where Sharewall has become an integral part of collaboration. Sharewall has made sure that our customers no longer have to choose between quality and flexibility in their frameless whiteboards – they can have both."
The International Interior Design Association (IIDA) is a professional networking and educational association. Their inaugural 2013 Innovation Awards at the National School Supply and Equipment Association (NSSEA) Ed Spaces exposition were designed to acknowledge and applaud outstanding products for the educational environment.
Interiors & Sources Magazine is a trade publication focused on serving interior designs for commercial spaces. Readers were asked to vote online to pick their favorite products from a variety of categories for the 2013 Readers' Choice awards.
CLEVELAND, OH —Winter 2013/2014 — Mobile Clean & Go™, a brand of DF Consumer Products, Inc., will officially launch its MiniMicro™ Triplepak and MegaMicro™ cleaning cloths at the I-X Christmas Connection running November 22–24 in Cleveland, OH.
The new MegaMicro cloth is designed for cleaning larger displays, tablets, computer monitors, TV screens and marine electronics. The MiniMicro Triplepak offers three refill microfiber pads for the popular Mobile Clean & Go Starter Kit and Value Pack.
“Our customers provided us with valuable product feedback and we listened,” Lad Ferian, Chief Executive Officer of DF Consumer Products, Inc. said. “The MiniMicro Triplepak and MegaMicro are perfect compliments to Mobile Clean & Go’s screen cleaning solution, and are great stocking stuffers for the holidays. We are pleased to launch the products at Cleveland’s premier holiday shopping event.”
Both products feature Mobile Clean & Go’s exclusive Dual-Hybrid™ technology offering two cleaning surfaces in one unique cloth design: a textured side for quick removal of fingerprints, dirt, grime, water spots and sunscreen; and a smooth optical-grade microfiber side to polish the screen to a crystal clear shine.
Mobile Clean & Go safely and effectively cleans screens on devices such as tablets, laptops, and smart phones, leaving screens free of fingerprints, dirt, and germs. Featuring a compact, flat spray bottle, a microfiber cleaning pad, and a vinyl sleeve for portability, the Mobile Clean & Go kit is smaller than a smart phone and slips easily into any locker, student desk, or backpack.
Mobile Clean & Go MiniMicro™ Triplepak ($4.99) and MegaMicro™ ($8.99) are available for immediate purchase through the online store at www.shop.mobilecleanandgo.com.
About Mobile Clean & Go Mobile Clean & Go is a division of DF Consumer Products, Inc. based in Berea, OH U.S.A. and has innovated in surfactant and surface cleaning chemistry since 2006. Our mission is to provide consumers with the most portable, effective cleaning system for their mobile electronics. All products are proudly made in the U.S.A. For more information visit our website at www.mobilecleanandgo.com, Facebook /mobilecleanandgo, or Twitter @MobileCleanNGo.
Mobile Clean & Go products do double duty….
Mobile Screen Cleaning Kit Battles Smart Phone Acne
Mobile Clean and Go™ mobile screen cleaning products, was recommended as one of the best travel-sized cleanser and cloth as a first line in the defense against germs that cause acne - citing noted New York City cosmetic dermatologist, Paul Jarrod Frank, MD (on a top beauty Flash Segment, September 20, 2013).
National Enzyme Company (NEC) celebrated the recent launch of their industry-first, customer portal “My NEC Connection.” NEC prides themselves on creating unique and valuable ways to make doing business easier and their customer-driven technology offerings now include an industry-first portal with their customer’s needs front and center.
This new portal will give customers the ability to view and track orders from start to finish 24/7. Customers can see their order history in addition to viewing products, retrieving shipping details and label information including quantity on hand, quantity ordered and quantity available. “We’re estatic to offer our customers this new tool. We realize they have a business to run and we want to make it as easy as possible to do business with us,” said Melony Fuller, NEC Director of Marketing.
Independently certified for cGMP compliance by NSF and TGA, NEC has the expertise to produce a broad range of dietary supplements including enzyme-based formulations, probiotics, vitamins, minerals, botanicals and more. We offer state-of-the-art manufacturing facilities with blending, encapsulation, tableting, convenience packaging, full service bottling, and in-house graphics/labeling services to meet the unique needs of our valued customers. We work tirelessly to help our customers create robust, profitable products, which impact the nutritional industry in a positive and progressive manner.
For more information about National Enzyme Company, please visit
www.nationalenzyme.com.
Heiser Automotive Group is prepared to help Southeastern Wisconsin businesses take advantage of an important tax deduction. This opportunity, via Tax Code 179, can be facilitated by the local dealership group. The incentive encourages businesses to buy equipment and invest in themselves before the end of the year.
Tax Code 179 allows businesses to deduct the full purchase price of qualifying equipment purchased or financed during the tax year. That means that if you buy (or lease) a qualifying vehicle for business use from Heiser Toyota, Heiser Ford or Heiser Chevrolet (two locations), you can deduct the FULL PURCHASE PRICE from your gross income. Heiser can also offer competitive rates, along with the outstanding factory incentives.
“These benefits are still in effect, but expiring soon for the 2013 calendar year. As the economy improves, we’ve noted more business owners upgrading their vehicle fleet to take full advantage of the code,” stated Mary Ann Scaffidi. “Heiser is available to help speed the process as you choose from our inventory of over 1,000 vehicles.
The extensive inventory of new 2013 and 2014 Ford, Lincoln, Toyota, Scion, Chevrolet, and Cadillac vehicles are available on four Milwaukee-area Heiser lots. With the year-end uptick in sales, incentives have never been stronger. Now really is a great time to purchase or lease.
To take advantage of this offer, call (414) 577-1600. Heiser’s helpful Business Center staff is available to set up an appointment for a test drive. Or, view Heiser Automotive Group’s complete inventory and special online pricing at heiser.com.
About Heiser Automotive Group:
Family-owned, Heiser Automotive Group was established 97 years ago in Milwaukee. It’s dedicated to providing excellence throughout the customer’s sales experience. With a motto, “Anything’s Possible”, employees seek to add value every day in the community they serve.
* The tax incentives are available for depreciable tangible property that is acquired by purchases for use in active conduct of a trade or business. Additional limitations may apply, based on purchases- for the 2013 tax year. The aggregate deduction of $500,000 under is most beneficial to small businesses that place in service no more than 2,000,000 of “Section 179 property” during the year. Certain vehicles, models, and restrictions apply. Consult your tax professional for details.
National Enzyme Company (NEC) celebrated the recent launch of their industry-first, customer portal “My NEC Connection.” NEC prides themselves on creating unique and valuable ways to make doing business easier and their customer-driven technology offerings now include an industry-first portal with their customer’s needs front and center.
This new portal will give customers the ability to view and track orders from start to finish 24/7. Customers can see their order history in addition to viewing products, retrieving shipping details and label information including quantity on hand, quantity ordered and quantity available. “We’re estatic to offer our customers this new tool. We realize they have a business to run and we want to make it as easy as possible to do business with us,” said Melony Fuller, NEC Director of Marketing.
Independently certified for cGMP compliance by NSF and TGA, NEC has the expertise to produce a broad range of dietary supplements including enzyme-based formulations, probiotics, vitamins, minerals, botanicals and more. We offer state-of-the-art manufacturing facilities with blending, encapsulation, tableting, convenience packaging, full service bottling, and in-house graphics/labeling services to meet the unique needs of our valued customers. We work tirelessly to help our customers create robust, profitable products, which impact the nutritional industry in a positive and progressive manner.
For more information about National Enzyme Company, please visit
www.nationalenzyme.com.
In a major endorsement of the fusion energy research and development program of start-up Lawrenceville Plasma Physics (LPP), a committee of senior fusion researchers, led by a former head of the US fusion program, has concluded that the innovative effort deserves “a much higher level of investment … based on their considerable progress to date.” The report concludes that “In the committee’s view [LPP’s] approach to fusion power … is worthy of a considerable expansion of effort.”
Lawrenceville Plasma Physics has been developing an extremely low-cost approach to fusion power based on a device called the dense plasma focus (DPF). In contrast to the giant tokamak machines that have been the recipients of most fusion funding, a DPF can fit in a small room. LPP’s final feasibility experiments and planned commercial generators will use hydrogen-boron fuel, which produces no radioactive waste and promises extremely economical clean energy.
The committee of researchers was led by Dr. Robert Hirsch, a former director of fusion research for the US Atomic Energy Commission and the Energy Research and Development Agency. Other members of the committee were Dr. Stephen O. Dean, President of Fusion Power Associates and former director of fusion Magnetic Confinement Systems for the Department of Energy; Professor Gerald L. Kulcinski, Associate Dean for Research, College of Engineering, University of Wisconsin-Madison; and Professor Dennis Papadopoulos, Professor of Physics, University of Maryland. The committee was organized by Dr. Hirsch at the request of Mr. Alvin Samuels, an investor in LPP’s effort, to give an objective assessment of the program. Neither Mr. Samuels nor LPP had any control over the committee’s conclusions.
The committee’s report pointed to the “innovative thinking and experimental results achieved thus far by Mr. (Eric J.) Lerner and his team at LPP.” At the same time, the scientists did not minimize the remaining work that still needs to be done to experimentally validate the predictions of LPP’s theory of DPF functioning and lay the foundation for commercial fusion generators. Commenting on the report, LPP’s President and Chief Scientist Lerner said, “We agree with the review committee that several of our predictions still need to be proved in the laboratory, which is what we intend to do in the near future.”
The LPP team has stated that, given adequate funding, they can demonstrate in a year or two the scientific feasibility of fusion energy with the DPF and hydrogen-boron fuel, a combination the team calls “Focus Fusion.” They expect that a working prototype generator can then be developed in a few years more.
The review committee broadly supported that short-term timeframe, concluding: “While a number of near-term physics issues remain to be resolved, it is likely that with adequate financial support these matters could be addressed in a relatively short period of time, e.g. a few years.” If these issues are addressed, “the committee does not see any fundamental roadblock to power system viability.” In other words, a functioning, economical and clean new source of energy may soon become reality.
Maui Luxury Living is one of the first networks of Maui Luxury brands to create a robust marketing platform to connect new customers with local luxury businesses to drive sales. In an effort to scale things quickly, MLL has been busy recruiting new members who are looking to utilize cutting edge strategies and technology to advertise to a hard to reach demographic: Maui Vacationers.
Travelers are engaged and sophisticated in today’s world, purchasing plane tickets through their iPhone app and booking excursions with their iPads. This is undoubtedly transforming how consumers respond to traditional advertising methods. While not all niches are the same, it seems evident that businesses need to become savvier in how their message is being delivered. Maui Luxury Living took notice back in 2011. View the Maui Luxury Living Company Commercial at http://www.youtube.com/watch?v=He0XVsavtzg
“Many times it is challenging to deliver your marketing message to a specific demographic through traditional marketing methods because you are forced to wait for consumer response to see how effective your sales message is,” says CEO Jeff Swanson.
“While advertising in your local luxury publication or Real Estate magazine keeps your brand in the spot light, it might not always translate into a positive ROI or new customers,” Swanson continues. It seems Maui Luxury Living was looking for a way to establish an advertising platform that could easily engage consumers in a more direct manner so that results could be measured more quickly.
MLL wants to help local luxury businesses tap into the billion dollar tourism industry here in Maui. With over 3 million visitors to Maui each year, being able to leverage a cutting edge advertising platform certainly gives businesses an advantage when it comes to attracting new customers. “Because this is a network focused on the luxury market, it will be much easier for my business to be seen by a more targeted audience of consumers who are looking for other types of luxury brands on Maui”, says Bob Yeager of Heli Golf Hawaii who joined MLL last month.
Some would argue that those who are searching for luxury brands do not care about promotions and online coupons but a recent report by Finance Daily suggest otherwise. The short quiz centered around this question: Which group do you think is more likely to use online coupons when shopping—households with average incomes of $100k+, or those bringing in less than 35k. The results indicated that the wealthier household is twice as likely to use coupons as is a college educated consumer versus one who did not finish high school. The bottom line is that technology is now allowing people across the board to easily experience new products and services through exclusive online promotions.
“The premium offers aren’t the focal point of Maui Luxury Living, say’s Jeff Swanson, but what it does allow for is the targeted interaction between consumers and Maui businesses.” “If a couple is going through our website and finds a 5 star restaurant along the beach with a million dollar view, the 10% coupon is just an added incentive. If the service and food are great, maybe they’ll visit more than once during their stay or share the coupon on Facebook or with friends they know will be visiting Maui soon.” At the end of the day Maui Luxury Living brings together targeted consumers and the finest Maui has to offer. First time visitors to Maui, seasoned travelers and local residents alike now have a single portal to search out luxury products, services and activities that are of interest to them. The exclusive promo is simply icing on the cake!
If you’re looking for the best Maui has to offer, please visit Maui Luxury Living (http://www.mauiluxuryliving.com/) today. See what we’re all about. If your a Maui Luxury brand or are interested in learning more, please visit us online at Maui Luxury Living, or call us at 800-478-0233.
VIP Vacations attended the 6th Annual Gourmet Inclusive Vacation Consultant (GIVC) Awards and Sales and Marketing event by Karisma Resorts from November 13th to the 16th of 2013. This year’s award ceremony took place at El Dorado Royale in the Riviera Maya, Mexico.
The night of the award ceremony, which was streamed live by the Mexico News Network, VIP Vacations took home a total of 15 awards including the Top Selling Storefront Agent, a first for VIP Vacations.
Other awards included the Top 10 Producers of El Dorado Spa Resorts and Hotels and Top 10 Producers of Azul Resorts and Hotels. VIP Vacations has 5 GIVC Wedding Consultants for Karisma resorts and won Top 10 Wedding Producers for Azul Hotels. Jennifer Doncsecz and Lauren Leayman both won Top 10 Wedding Producers for El Dorado Resorts.
VIP Vacations also swept up the Diamond Awards. Jennifer Doncsecz won for the 2nd time the elite 5 Diamond Award, an achievement that indicates a high professional commitment exceeding service standards. Other Diamond Award winners were Alison Dobrowolski for 1 Diamond, 2 Diamond winner Lauren Leayman, and 4 Diamond winner Emily Fisher.
Launched in 2008, the GI Vacation Consultant Program (GIVC) is limited to an elite group of travel agents who are obligated to meet specific standards and requirements in order to exceed extremely high expectations with regards to customer service and support. Not only do GI Vacation Consultants receive benefits from the program—from marketing tools to added incentives to offer consumers—but travelers who book a vacation with the specialized agents are privy to exclusive deals and on-property VIP recognition as a GIVC guest, among other advantages.
VIP Vacations Inc. is a full service travel agency that has been in business since 1994 with offices in Pennsylvania, New York, New Jersey and North Carolina. VIP Vacations has won numerous awards from Karisma Resorts and also received the Caribbean Tourism Organizations' highly touted "Romance in Travel Award".
President, Jennifer Doncsecz is the featured travel expert for Martha Stewart's Weddings Magazine and destination wedding blogger for Bridal Guide. VIP Vacations specializes in destination weddings and honeymoons.
Los Angeles, CA – Homewood, an impoverished neighborhood on Pittsburgh’s East End, was called “one of America’s most dangerous neighborhoods” on MSNBC's Rachel Maddow Show in 2011. Violence, drugs and incarceration have plagued this working class community for nearly two decades. Eager to see a meaningful change in his community and a realistic portrayal of life as a young man growing up in the inner city, former Homewood resident, Olufemi Young of O.Y.’s Spotlite Entertainment, approached other former residents, Najaa Young and Rasheed Jihad, owners of NaRa Films, about co-producing a film set in Homewood. The result is the new, exciting and bold feature film, Blood First.
Blood First chronicles the lives of two brothers who haphazardly follow their father's footsteps into a dangerous life of crime and violence. When faced with serving lengthy prison sentences for their crimes one brother chooses to cooperate with the prosecution while the other does not, testing the meaning of loyalty, honor and blood. The film’s non-linear storytelling fluidly mixes the past with the present as audiences experience what events occurred in their lives to make these men who they are today. “People think of crime and violence as only affecting major cities like New York, LA and Chicago,” says writer/director, Najaa Young, “ but it is decimating communities in smaller cities too.”
The film, which boasts local talent from Pittsburgh, marks the debut of many of the cast members who enjoyed working alongside professional actors and crew. In addition, neighborhood residents enjoyed tours of the set, free food and beverages on sweltering summer days as well as the ability to meet the producers and director, not something done on the “Hollywood” films that often come to the city to shoot. Local business owners in the neighborhood also benefitted by having the Blood First production patronize them as customers for catering, meeting rooms and film locations. Producer Rasheed Jihad, says, “This film was a concerted effort to uplift our community by involving the community in the process, a first for a production of this magnitude.”
Blood First which is slated for release in 2014 boasts a powerful score by multiplatinum music producer Drumma Boy and original music by Project Pat, Big KRIT, Turk (of the Hot Boyz), 8 Ball, MJG and Emanuel “Manny” DeAnda (former lead singer of Pretty Ricky). Producer Olufemi Young says, “We were very fortunate to have artists of this caliber coming together to work on this project. With Drumma Boy overseeing the music we were able to deliver a film of the highest quality.”
Blood First has been rated R by the Motion Picture Association of America (MPAA). To learn more about the film and to see the trailer visit: www.BloodFirstTheMovie.com.
Radio 日本 証明規則第二条第一項第１９号に掲げる無線設備 アメリカ FCC CRF Title４７ Part１５ Subpart C カナダ IC RSS－２１０ 欧州 EN ３００ ３２８（２００６－１０） Safety 欧州 EN ６０９５０－１（２００６） 欧州 EN ６２４７９：２０１０ EMC 欧州 EN ３０１ ４８９－１（２０１１－０９） 欧州 EN ３０１ ４８９－１７（２００９－０５） Bluetooth BQE Listed QD ID：B０２１３０１，B０２１０８６ Environmental RoHS RoHS Compliance
iPhone，iPad and iPod touch are trademarks of Apple Inc．，registered in the U．S．and other countries．App Store is a service mark of Apple Inc． Android is a trademark of Google Inc．Google Play is a trademark of Google Inc．
丸紅株式会社（以下、丸紅）は、米国のEnerNOC，Inc．（以下、EnerNOC）と、日本においてデマンドレスポンス（※１、以下DR）を提供することを目的とした合弁会社を共同で設立することに合意いたしました。新しい合弁会社の名前はエナノック・ジャパン株式会社（英語表記 EnerNOC Japan KK、以下、エナノック・ジャパン）といい、同社はEnerNOCのクラウドベースのDRアプリケーションであるDemandSMART(TM)の日本における独占ライセンスを保有いたします。
第一三共株式会社（本社：東京都中央区、以下「当社」）は、当社が創製した抗凝固剤（経口FXa阻害剤）エドキサバン（一般名：エドキサバントシル酸塩水和物）の深部静脈血栓症（DVT）、肺塞栓症（PE）患者における静脈血栓塞栓症（VTE）の治療および再発抑制に関する第３相臨床試験（Hokusai－VTE試験）に登録されたがん患者に対するサブグループ解析の結果が、米国・ニューオリンズで開催中の米国血液学会議（American Society of Hematology：ASH）２０１３において発表されましたので、その概要をお知らせします。
本サブグループ解析は、Hokusai－VTE試験に参加した、がんに罹患している患者（２０８名）とがん既往歴のある患者（５６３名）、合計７７１名を対象に、エドキサバンを１日１回経口投与したときの有効性と安全性をワルファリンと比較したものです。有効性の主要評価項目であるVTEの発現率は、エドキサバン群で３．７％、ワルファリン群で７．１％であり、エドキサバン群で低値でした（HR ０．５３、９５％ CI ０．２８－１．００）。また、安全性に関して、臨床的に重要な出血（重大な出血、もしくは重大ではないが臨床的に重要な出血）の発現率は、エドキサバン群で１２．４％、ワルファリン群で１８．８％であり、エドキサバン群で低値でした（HR ０．６４、９５％ CI ０．４５－０．９２）。８，２９２名の患者を対象としたHokusai－VTE試験では、エドキサバンは１日１回経口投与によりワルファリンに対して、有効性で非劣性、安全性において優越性を示しましたが、がん患者を対象としたこのサブグループ解析においても、Hokusai－VTE試験の全体で見た結果と同様の有効性と安全性が示されました。
がんに罹患している２０８名の患者におけるVTEの再発率は、エドキサバン群で３．７％、ワルファリン群で７．１％であり（HR ０．５５、９５％ CI ０．１６－１．８５）、臨床的に重要な出血の発現率は、エドキサバン群で１８．３％、ワルファリン群で２５．３％でした（HR ０．７２、９５％ CI ０．４０－１．３０）。
＜Hokusai－VTE試験について＞ Hokusai－VTE試験は、国際共同、無作為化、二重盲検、第３相臨床試験であり、急性症候性の深部静脈血栓症（deep vein thrombosis：DVT）患者、または、肺塞栓症（pulmonary embolism：PE）患者における症候性静脈血栓塞栓症（venous thromboembolism：VTE）の治療および再発抑制に関するエドキサバンを１日１回経口投与したときの有効性と安全性を評価する臨床試験であり、３７ヶ国の４３９の医療機関において８，２９２人の患者が登録されました。本試験では、実医療を反映して、がん患者を含む広範囲のVTE患者に対し、標準治療法であるヘパリンの初期治療に続き、エドキサバン、または、ワルファリンが、３～１２ヶ月間投与されました。 Hokusai－VTE試験の結果については、オランダ・アムステルダムで開催された欧州心臓病学会２０１３において発表されると共に、New England Journal of Medicineに掲載されました。有効性の主要評価項目であるVTEの発現率は、エドキサバン群で３．２％、ワルファリン群で３．５％であり、エドキサバンのワルファリンに対する非劣性が検証されました（HR ０．８９、９５％ CI ０．７０－１．１３；P＜０．００１［非劣性］）。再発性症候性VTEは、１２ヶ月間の試験期間における、再発性症候性のDVTと、非致死性の症候性PEおよび致死性のPEの複合と定義されています。 また、安全性に関して、臨床的に重要な出血（重大な出血、もしくは重大ではないが臨床的に重要な出血）の発現率は、エドキサバン群で８．５％、ワルファリン群で１０．３％であり、エドキサバンのワルファリンに対する優越性が示されました（HR ０．８１、９５％ CI ０．７１－０．９４；P＝０．００４［優越性］）。 本サブグループ解析は、Hokusai－VTE試験に登録された患者のうち、低分子ヘパリンの長期投与が予定されていない、がんに罹患している患者（２０８名）とがん既往歴のある患者（５６３名）、合計７７１名を対象に実施されたサブグループ解析です。低分子ヘパリンの長期投与が予定されている患者は、本試験から除外されました。
